A survey of the educational and employment experiences of the 1948-1952 Wilmington High School business graduates with implications for curriculum revision.

Thesis (M.A.)--Boston Universit

IDENTIFICATION OF SUBTYPES OF LEARNING-DISABLED CHILDREN WITH ARITHMETIC DISORDERS: A NEUROPSYCHOLOGICAL, MULTIVARIATE ANALYSIS.

Previous characterizations of arithmetic disabled children with intact reading skills have been rather discrepant. The purpose of the present study was to first determine whether or not a sample of arithmetric disabled children with intact reading skills was, in fact, heterogeneous with respect to their patterns of academic performances on the Wide Range Achievement Test (WRAT) Reading, Spelling, and Arithmetic subtests. If this sample of children was indeed heterogeneous, would the resulting subtypes of children differ with respect to their patterns of neurocognitive skills and their ratings on a measure of personality functioning (i.e., PIC: Personality Inventory for Children). A group of 156 children exhibiting WRAT Arithmetic centile scores less than 27 and Reading centile scores greater than 40 were culled from a database of over 4800 children who had been referred to a multi-servive mental health clinic because of suspected central processing deficiencies. All 156 children were between the ages of 9-14 years, obtained Full Scale IQ\u27s between 85-115 on the Wechsler Intelligence Scale for Children (WISC), and were free from any visual or auditory perceptual acuity deficiencies and environmental deprivation. All children spoke English as their primary language. In order to determine if this sample of children was indeed heterogeneous with respect to academic performances, WRAT Reading, Spelling and Arithmetic scores were subjected to several hierarchical clustering procedures. Concurrent validation of the cluster solutions was provided by multivariate and univariate analysis of variance using variables not included in the initial classification: 22 neuropsychological measures and selected PIC scales. Application of the initial cluster analytic techniques and subsequent validation procedures suggested the presence of four subtypes which were differentiated significantly on academic, neurocognitive and personality measures.Dept. of Psychology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1986 .D458. Source: Dissertation Abstracts International, Volume: 48-07, Section: B, page: 2115. Thesis (Ph.D.)--University of Windsor (Canada), 1987

THE INNER ALCHEMY OF BUDDHIST TANTRIC MEDITATION: A QEEG CASE STUDY USING Low RESOLUTION ELECTROMAGNETIC TOMOGRAPHY (LORETA)

Indo-Tibetan Buddhist T~mtric practice employs struClured self-healing meditations aimed at awakening emotional and spitiruai qualities or energies whose seed already resides within us. This profound transfi)rmative pranice. with wrirren records dating back to at least 400 c.E., is investigated from several diverse orienrations: depth psychology. neuropsychology, and neurophysiology. from a Jungian perspecrive. the psychological process of this pracrice involves the re-collection and development of these energies to engender emotional and spirirual growth. Using a phenomenological task analysis. the various nemocognitive processes involved in such practice are identitied. Finally. we analyze the qU3mitative electroencephalographic (QEEG) characreristics of a Buddhisr ex-monk during various aspects of a self-healing meditation practice. The QEEG was recorded with a Lexicor Neuroseatch 24 ,md data analyzed using NeuroRep, NeuroGuidc. LORETA-KEY and EureKa!3 software. EEG rderence database, as well low resolution electromagnetic tomography (LORETA), Staristical comparison of baseline and meditation conditions using LORETA revealed areas of brain activation consistent with those reponed in previolls neuroimaging studies. The QEEG results are discussed in the context of the phenomenological processes involved in the differenr types of meditation as well as with results of previolls srudies

Novel psychoactive substances (NPS) – knowledge and experiences of drug users from Hungary, Poland, the UK and the USA

Submitted 19 September 2019; Accepted 29 November 2019; Proof received 29 November 2019; Published 18 February 2020. Note: No DOI allocated.Dopamine D 3 receptor partial agonists represent a new generation of atypical antipsychotics. Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment of adult patients with schizophrenia (including those with predominant negative symptoms of schizophrenia) differs from the other two partial agonist antipsychotics aripiprazole and brexpiprazole due to its unique features. Cariprazine is a dopamine D 3 preferring D 3/D2 partial agonist with very similar dopamine receptor sub-type selectivity as dopamine. It has proven efficacy in the treatment of positive and negative symptoms of schizophrenia, as well as for relapse prevention. Further phase-3 clinical studies proved the efficacy of cariprazine in the acute treatment of manic or mixed episodes associated with bipolar I disorder, as well as in bipolar depression. For the adjunctive treatment of major depressive disorder, phase 3 studies are in progress.Peer reviewedFinal Published versio

Course of Untreated High Blood Pressure in the Emergency Department

<p>Introduction: No clear understanding exists about the course of a patient’s blood pressure (BP) during an emergency department (ED) visit. Prior investigations have demonstrated that BP can be reduced by removing patients from treatment areas or by placing patients supine and observing them for several hours. However, modern EDs are chaotic and noisy places where patients and their families wait for long periods in an unfamiliar environment. We sought to determine the stability of repeated BP measurements in the ED environment.</p> <p>Methods: A prospective study was performed at an urban ED. Research assistants trained and certified in BP measurement obtained sequential manual BPs and heart rates on a convenience sample of 76 patients, beginning with the patient arrival in the ED. Patients were observed through their stay for up to 2 hours, and BP was measured at 10-minute intervals. Data analysis with SAS PROC MIXED (SAS Institute, Cary, North Carolina) for regression models with correlated data determined the shape of the curve as BP changed over time. Patients were grouped on the basis of their presenting BP as normal (less than 140/90), elevated (140–160/90–100), or severely elevated (greater than 160/100) for the regression analysis.</p> <p>Results: A statistically significant downward trend in systolic and diastolic BP was observed only for those patients presenting with severely elevated BPs (ie, greater than 160/100).</p> <p>Conclusion: We demonstrate a statistically significant decline in systolic and diastolic BP over time spent in the ED only for patients with severely elevated presenting BPs. [West J Emerg Med. 2011;12(4):421–425.]</p

NF-κB Protects HIV-1-Infected Myeloid Cells from Apoptosis

AbstractHIV-1 infection of primary monocytic cells and myeloid cell lines results in sustained NF-κB activation. Recently, NF-κB induction has been shown to play a role in protecting cells from programmed cell death. In the present study, we sought to investigate whether constitutive NF-κB activity in chronically HIV-1-infected promonocytic U937 (U9-IIIB) and myeloblastic PLB-985 (PLB-IIIB) cells affects apoptotic signaling. TNFα and cycloheximide caused infected cells to undergo apoptosis more rapidly than parental U937 and PLB-985 cells. Inhibition of TNFα-induced NF-κB activation using the antioxidantN-acetylcysteine (NAC) resulted in increased apoptosis in both U937 and U9-IIIB cells, while preactivation of NF-κB with the non-apoptotic inducer IL-1β caused a relative decrease in apoptosis. Inhibition of constitutive NF-κB activity in U9-IIIB and PLB-IIIB cells also induced apoptosis, suggesting that NF-κB protects cells from a persistent apoptotic signal. TNFα plus NAC treatment resulted in a marked decrease in Bcl-2 protein levels in HIV-1-infected cells, coupled with an increase in Bax protein compared to uninfected cells, suggesting that the difference in susceptibility to TNFα-induced apoptosis may relate to the differences in relative levels of Bcl-2 and Bax. The protective role of NF-κB in blocking TNFα- and HIV-1-induced apoptosis was supported by studies in Jurkat T cells engineered to express IκBα repressor mutants (TD-IκB) under the control of a tetracycline-responsive promoter. Cells underwent apoptosis in response to TNFα only when NF-κB activation was inhibited by TD-IκB expression. As was observed for the U9-IIIB cells, TNFα treatment also induced a marked decrease in Bcl-2 protein levels in TD-IκB expressing cells. These experiments demonstrate that apoptotic signaling is perturbed in HIV-1-infected U9-IIIB cells and indicate that NF-κB activation may play an additional protective role against HIV-1-induced apoptosis in myeloid cells

A Pilot Study Examining Speed of Processing Training (SPT) to Improve Processing Speed in Persons With Multiple Sclerosis

Background: Individuals with Multiple Sclerosis (MS) have significant impairments in processing speed (PS) and such impairments may underlie other cognitive deficits common in MS and limit performance of everyday life activities.Objective: To examine the efficacy of a computerized PS intervention, Speed of Processing Training (SPT), in persons with MS on PS, memory and everyday activities.Methods: Twenty-one individuals with clinically definite MS and an objectively assessed impairment in PS were included in a controlled randomized clinical trial, randomly assigned to a treatment group or a control group. Participants were assessed prior to and within 1 week of completing the treatment. Outcome measures included traditional neuropsychological tests measuring PS and memory, and an assessment of PS in daily life activities.Results: The treatment group showed a significant improvement on neuropsychological tests of PS and new learning and memory. A significant improvement was additionally noted in the treatment group on measures of PS in everyday life. These changes were not observed in the control group.Conclusions: Results provide preliminary data in support of SPT in treating PS deficits in persons with MS. Additional research is needed with larger samples and more comprehensive outcome measures

The temporal dynamics of visual processing in multiple sclerosis

Although the integrity of the visual system is often affected in multiple sclerosis (MS), the potential relationship between the temporal dynamics of visual processing and performance on neuropsychological tests assessing processing speed (PS) remains relatively unexplored. Here, we test if a PS deficit is related to abnormalities within the visual system, rather than impaired higher-level cognitive function. Two groups of participants with MS (1 group with PS deficits and another without) and a healthy control group, matched for age and education, were included. To explore the temporal dynamics of visual processing, we used 2 psychophysical paradigms: attention enhancement/prioritization and rapid serial visual presentation. Visual PS deficits were associated with a decreased capability to detect visual stimuli and a higher limitation in visual temporal-processing capacity. These results suggest that a latent sensorial temporal limitation of the visual system is significantly associated to PS deficits in MS.This work was supported by the Foundation for Science and Technology of Portugal with a doctoral fellowship grant (No. SFRH/BD/455591/2008) to SLC. JA is supported by funding from the Foundation for Science and Technology of Portugal Project Grants PTDC/PSI-PCO/114822/2009 and PTDC/MHC-PCN/3575/2012.info:eu-repo/semantics/publishedVersio